Infectious diseases are responsible for one third of all deaths worldwide, killing at least 15 million people a year. Of these, more than five million are children under five years of age. In addition, infectious diseases significantly disable millions more.
The most effective way to reduce disease and death from infectious diseases is to vaccinate susceptible populations. The impact of vaccination on the health of the world’s population cannot be overstated. Their impact on reducing morbidity and mortality is greater than the advent of antibiotics. Although highly effective, vaccines are available against a limited number of pathogens. For other infectious diseases vaccines are either unavailable or offer partial protection. In many cases this is due to the absence of effective antigens required to generate immunogenic responses.
Lung cancer is the third most common cancer and the most common cause of cancer-related deaths in both men and women. According to the American National Cancer Institute (NCI), there were 213,380 estimated new cases of lung cancer and 160,390 deaths in the United States in 2007.
The low five-year survival rate (15%) is due to the high recurrence rate of lung cancer and to the fact that no effective treatment for preventing metastasis is yet available.